Medicine MCQs for AMC Part 1 Exam
Question 1001
A 45-year-old male presents to your clinic for a routine check-up. He has no significant medical history and is not taking any medications. On examination, his blood pressure is consistently measured at 160/100 mm Hg on multiple occasions, both at rest and during the visit. He denies any symptoms such as headaches, blurred vision, or chest pain. There is no evidence of end-organ damage on examination, and laboratory tests are within normal limits. What is the most likely diagnosis?
- A) Mild Hypertension
- B) Moderate Hypertension
- C) Severe Hypertension
- D) Hypertensive Urgency
- E) Hypertensive Emergency
Question 1003
A 42-year-old woman presents to her rheumatologist with a complaint of joint pain and stiffness, which has been progressively worsening over the past few months. She notes that her symptoms are most severe in the morning and typically last for more than 30 minutes. On examination, you observe bilateral swelling and tenderness in her wrists and metacarpophalangeal joints. There are also noticeable deformities in her fingers with ulnar deviation. Laboratory tests reveal a positive rheumatoid factor and elevated anti-cyclic citrullinated peptide (anti-CCP) antibodies. What is the most likely diagnosis?
- A) Osteoarthritis
- B) Gout
- C) Systemic lupus erythematosus
- D) Ankylosing spondylitis
- E) Rheumatoid arthritis
Question 1004
A 32-year-old male with a known history of type 1 diabetes mellitus presents to the emergency department with complaints of excessive thirst, frequent urination, abdominal pain, and deep rapid breathing. He mentions that he has missed his insulin injections for the past few days. On examination, he appears dehydrated, with dry mucous membranes and fruity breath. His vital signs show tachycardia and hypotension. Laboratory tests reveal hyperglycemia, ketonemia, and metabolic acidosis. Which of the following is the most likely diagnosis?
- A) Diabetic ketoacidosis
- B) Hyperosmolar hyperglycemic state
- C) Hypoglycemia
- D) Type 2 diabetes mellitus
- E) Diabetic nephropathy
Question 1005
A 60-year-old male presents to a neurologist with complaints of resting tremors, rigidity, and bradykinesia. His family reports that he has been experiencing these symptoms for the past year, and they have progressively worsened. On examination, the patient exhibits a resting tremor, cogwheel rigidity, and a shuffling gait. There is also a masked facies with reduced blinking. Which of the following is the most likely diagnosis?
- A) Alzheimer’s disease
- B) Multiple sclerosis
- C) Parkinson’s disease
- D) Huntington’s disease
- E) Amyotrophic lateral sclerosis
Question 1006
A 30-year-old woman presents with fatigue, pallor, and jaundice. Her medical history reveals a family history of a similar condition. Physical examination shows scleral icterus and hepatosplenomegaly. Laboratory tests indicate a low hemoglobin level, an elevated reticulocyte count, and a positive Coombs test. What is the most likely diagnosis?
- A) Iron-deficiency anemia
- B) Vitamin B12 deficiency anemia
- C) Hemolytic anemia
- D) Aplastic anemia
- E) Thalassemia
Question 1007
A 45-year-old man presents to his primary care physician with complaints of fatigue, easy bruising, and recurrent nosebleeds over the past several weeks. On physical examination, there are no remarkable findings, except for petechiae and ecchymoses on his skin. Laboratory tests reveal a low red blood cell count, low platelet count, and a high white blood cell count. A bone marrow biopsy is performed, and the results show hypercellularity with increased blast cells. What is the most likely diagnosis?
- A) Leukemia
- B) Lymphoma
- C) Multiple myeloma
- D) Aplastic anemia
- E) Hemophilia
Question 1008
A 28-year-old woman presents to you with a history of fatigue, joint pain, and a butterfly-shaped rash on her face that worsens with sun exposure. She also reports hair loss and oral ulcers. On examination, you note joint tenderness, swelling in her fingers, and a characteristic malar rash on her cheeks. Laboratory tests reveal positive antinuclear antibodies (ANA), anti-dsDNA antibodies, and low complement levels. What is the most likely diagnosis?
- A) Rheumatoid arthritis
- B) Sjögren’s syndrome
- C) Systemic sclerosis (scleroderma)
- D) Systemic lupus erythematosus
- E) Psoriatic arthritis
Question 1009
A 30-year-old woman presents to you with a history of episodic neurological symptoms, including visual disturbances, weakness in her legs, and difficulty with coordination. She mentions that these episodes tend to come and go over the past few years, with some periods of remission in between. On examination, you find evidence of abnormal reflexes, muscle weakness, and positive findings on an MRI of the central nervous system. Which of the following is the most likely diagnosis?
- A) Migraine
- B) Epilepsy
- C) Myasthenia gravis
- D) Multiple sclerosis
- E) Parkinson’s disease
Question 1010
A 32-year-old woman presents to you with complaints of chronic abdominal pain, diarrhea, and occasional rectal bleeding. She reports that her symptoms have been ongoing for several months and are not relieved by over-the-counter medications. On examination, you note tenderness in the lower abdomen. Laboratory tests show elevated inflammatory markers. Colonoscopy reveals skip lesions with aphthous ulcers and areas of cobblestone appearance in the colon. What is the most likely diagnosis?
- A) Irritable bowel syndrome
- B) Diverticulitis
- C) Gastroenteritis
- D) Inflammatory bowel disease
- E) Celiac disease
